丹荷颗粒治疗高脂血症质量标志物发现研究

为寻找丹荷颗粒治疗高脂血症的质量标志物,该研究基于丹荷颗粒体内成分分析结果,采用Cytoscape软件构建高脂血症-共有靶点-丹荷颗粒体内成分作用网络,利用DAVID及String数据库分别对共有靶点进行生物过程、通路富集及网络拓扑分析,明确丹荷颗粒降脂作用关键靶点及成分,再建立油酸诱导的HepG2细胞脂质堆积模型验证关键成分的降脂药效,最后结合相关成分在制剂中的含量、稳定性、特征性综合确定质量标志物。结果发现,丹荷颗粒体内成分作用于CES1、ADORA2A、ADORA1、APOB、LDLR、PPARA、PPARG、INSR、ESR2、ESR1共10个高脂血症疾病靶点,主要参与脂质代谢过程以及PPAR、cAMP信号通路,其中LDLR、PPARA、PPARG可能是关键靶点,而网络中与关键靶点直接作用的成分为白藜芦醇、柚皮素。白藜芦醇和柚皮素均可降低油酸诱导的HepG2细胞内脂滴数量,改善细胞脂质堆积严重程度,并显著降低细胞内甘油三酯含量,可能为关键成分;鉴于入体成分白藜芦醇和柚皮素来源于制剂中虎杖苷及柚皮苷,且制剂中虎杖苷及柚皮苷特征明显、含量丰富、稳定,故虎杖苷及柚皮苷可作为丹荷颗粒治疗高脂血症的质量标志物。该研究为丹荷颗粒质量标准的建立提供了合理的候选质控指标。     

Synthesis of linseed oil based biodegradable homo and copolymers: role as multifunctional greener additives in lube oil

Abstract

Homopolymer of linseed oil and its four copolymers with styrene, 1-decene, isodecyl acrylate and octyl acrylate, respectively, have been synthesized in this present context. The prepared polymers are characterized by NMR and FTIR spectroscopy. The molecular weights have been measured by gel permeation chromatography. Their effectiveness as pour point depressant (PPD), viscosity index improver (VII) and their shear stability in terms of permanent shear stability index have been evaluated in lube oil. The copolymers acted as better PPDs than the homopolymer whereas the homopolymer of linseed oil excelled as VII. Further it was observed that all the prepared polymers were stable enough under severe mechanical shear.     

用于宽谱带发射白色发光二极管的黄色荧光粉Sr8MgAl(PO4)7∶xEu2+的制备及发光性能

通过高温固相反应合成了一系列宽谱带发射黄色荧光粉Sr_8MgAl(PO_4)_7∶x Eu~(2+)(SMAP∶x Eu~(2+)),并对其物质结构、发光性能及其在白色发光二极管(WLED)领域的应用进行了探究。X射线衍射(XRD)测试结果表明,SMAP∶x Eu~(2+)系列荧光粉具有单斜结构和C2/m空间群,激活剂Eu~(2+)离子能够很好地进入SMAP基质中并占据Sr~(2+)离子的晶格位点。漫反射光谱分析显示SMAP基质属于宽带隙材料,带隙宽度为3.60 e V。此外,SMAP∶x Eu~(2+)具有较宽的激发范围(280～500 nm),对应于Eu~(2+)离子的4f~7→4f~65d~1跃迁;在380 nm近紫外光激发下,呈现出450～800 nm的多发光中心的非对称黄光发射,发射峰位于590 nm处。基于高斯多峰拟合结果,得到3个发光中心,分别位于528、600和680 nm。最后,将已制备的黄色荧光粉SMAP∶0.05Eu~(2+)与商业化蓝粉Ba Mg Al_(10)O_(17)∶Eu~(2+)混合涂覆到400 nm芯片上制得色温较好(3 344 K)、显色指数较高(90.1)的WLED。     

An Easy Synthesis of Monofluorinated Derivatives of Pyrroles from β-Fluoro-β-Nitrostyrenes

The catalyst-free conjugate addition of pyrroles to β-Fluoro-β-nitrostyrenes was investigated. The reaction was found to proceed under solvent-free conditions to form 2-(2-Fluoro-2-nitro-1-arylethyl)-1H-pyrroles. The effectiveness of this approach was demonstrated through the preparation of a series of the target products in a quantitative yield. The kinetics of a conjugate addition of pyrrole was studied in detail to reveal the substituent effect and activation parameters of the reaction. The subsequent base-induced elimination of nitrous acid afforded a series of novel 2-(2-Fluoro-1-arylvinyl)-1H-pyrroles prepared in up to an 85% isolated yield. The two-step sequence herein proposed is an indispensable alternative to a direct reaction with elusive and unstable 1-Fluoroacetylenes.     

Volumetric properties,viscosities and refractive indices of binary liquid mixtures of tetrafluoroborate-based ionic liquids with methanol at several temperatures

Densities, speeds of sound, viscosities and refractive indices of two binary systems 1-butyl-3-methylimidazolium tetrafluoroborate [bmim][BF₄] + methanol and 1-ethyl-3-methylimidazolium tetrafluoroborate [emim][BF₄] + methanol, as well as of all pure components, have been measured covering the whole range of compositions at T = (278.15 to 318.15) K and p = 101 kPa. From this data, excess molar volumes, excess isentropic compressibilities, viscosity deviations and refractive index deviations were calculated and fitted to extended versions of the Redlich–Kister equation. Estimated coefficients of these equations taking into account the dependence on composition and temperature simultaneously were also presented.     

Role of refractive index in sum frequency generation intensity of salt solution interfaces

Sum frequency generation spectroscopy (SFG) has been widely used to study the interfacial chemistry of aqueous salt solutions of biological or environmental importance. Most of the SFG data analysis used the same bulk refractive index for different salt concentrations despite of the variations of the refractive indices. Here we systematically investigate the influence of the refractive index on the SFG intensities at various experimental conditions. It is discovered that the SFG intensities are the most sensitive to the refractive index at solid/liquid interfaces nearby the total internal reflection geometries. At air/liquid interfaces, the effect of the refractive indices is also nonegligible. Consequently some important SFG results, such as the response of water structures to the ionic strength at the SiO₂/aqueous interfaces, are necessary to be reevaluated. These conclusions on the effect of the small variations of the refractive index are generally useful for the common practice of SFG data analysis.     

甲氧基多溴联苯醚色谱相对保留时间的QSRR研究

基于有机化合物定量结构与色谱相对保留时间的关系,对26个甲氧基多溴联苯醚化合物进行了B3LYP/6-31G*水平上的结构优化,并在优化结构基础上进行了分子连接性指数和量子化学结构参数的提取。应用SPSS统计软件对甲氧基多溴联苯醚化合物的色谱相对保留时间与分子连接性指数进行了多元线性回归(MLR)。结果表明,三阶类分子连接性指数可以很好地表达甲氧基多溴联苯醚化合物色谱相对保留时间与结构描述符之间的定量关系。用外部测试集的方法对模型预测能力进行了验证,结果表明:所建立的QSRR模型具有较强的稳健性和预测能力。     

Refractive index of benzene and methyl derivatives: temperature and wavelength dependencies

Measurements of the refractive index from 288 to 318 K at five fixed wavelengths, from 656.3 to 404.7 nm, are reported for benzene, toluene (methylbenzene), o-xylene (1,2-dimethylbenzene), m-xylene (1,3-dimethylbenzene), and p-xylene (1,4-dimethylbenzene). We also report the temperature and wavelength dependencies of the refractive index obtained from a least-squares routine. The agreement between the measured and calculated refractive indices lies within the experimental uncertainty.     

蒙皂石含量与膨胀土膨胀势指标相关关系研究

对沿南水北调中线工程邯郸—永年、南阳、平顶山等地区及襄樊、荆门钟祥地区采集的各类地表、近地表膨胀土样品5 6件 ,运用现代XRD定量方法和有机染料吸附方法测量了粘土矿物成分和蒙皂石含量 ,同时测定了它们的液限、塑限、自由膨胀率、比表面积、粘粒、胶粒含量等指标。蒙皂石含量与各种膨胀势判别指标研究表明 ,蒙皂石含量是各种膨胀势的主要控制因素。当然 ,各种测量误差 (主要是蒙皂石含量的测量误差 )也是影响膨胀势判别的因素。Seed膨胀势较本文采用的推荐方案划分结果高 1～ 2个级次。蒙皂石含量与各参量之间呈线性、对数、指数关系 ,与粘土矿物的“诊断”吸收特性一起 ,这为膨胀土遥感提供了基础.